羧酸轉化為Barton酯，然后進行自由基脫羧的反應。
反應機理
反應實例
此反應中沒有加入氫化錫，而是生成硫醚中間體，然后消除。
參考文獻
Barton, D. H. R.; Crich, D.; Motherwell, W. B. J. Chem. Soc., Chem. Commun. 1983,939-941. Sir Derek Barton (United Kingdom, 1918-1998) studied under Ian Heilbron at Imperial College in his youth. He taught in England, France and the US. Barton won the Nobel Prize in Chemistry in 1969 for development of the concept of conformation. He passed away in his office at the University of Texas A&M in 1998. Derek Barton先生（英國化學家，1918-1998），年輕時在倫敦帝國理工學院學習，師從 Ian Heilbron。后來又在英國，法國和美國教學。他由于在有機化學構象方面的研究獲得了1969年的諾貝爾化學獎。他于1998年德克薩斯A&M大學的辦公室內去世。
Barton, D. H. R.; Zard, S. Z. Pure Appl. Chem. 1986, 58, 675-684. (Review).
Cochane, E. J.; Lazer, S. W.; Pinhey, J. T.; Whitby, J. D. Tetrahedron Lett. 1989, 30, 7111-7114.
Barton, D. H. R. Aldrichimica Acta 1990, 23, 3. (Review).
Crich, D.; Hwang, J.-T.; Yuan, H. J. Org. Chem. 1996, 61, 6189-6198.
Yamaguchi, K.; Kazuta, Y.; Abe, H.; Matsuda, A.; Shuto, S. J. Org. Chem. 2003, 68, 9255-9262.
Zard, S. Z. Radical Reactions in Organic Synthesis Oxford University Press: Oxford, UK, 2003. (Book).
Carry, J.-C.; Evers, M.; Barriere, J.-C.; Bashiardes, G.; Bensoussan, C.; Gueguen, J.-C.; Dereu, N.; Filoche, B.; Sable, S.; Vuilhorgne, M.; Mignani, S. Synlett 2004, 316-320.
Brault, L.; Denance, M.; Banaszak, E.; El Maadidi, S.; Battaglia, E.; Bagrel, D.; Samadi, M. Eur. J. Med. Chem. 2007, 42, 243-247.
Guthrie, D. B.; Curran, D. P. Org. Lett. 2009, 11, 249-251.
He, Z.; Trinchera, P.; Adachi, S.; St. Denis, J. D.; Yudin, A. K. Angew. Chem. Int. Ed. 2012, 51, 11092–11096.
編譯自：J.J. Li, Name Reactions: A Collection of Detailed Mechanisms and Synthetic Applications, Barton radical decarboxylation，page 26-27.
