Glaser偶聯(lián)是通過(guò)兩個(gè)端基炔合成對(duì)稱二炔或環(huán)狀二炔的常用反應(yīng)。機(jī)理上與Eglinton 反應(yīng)類似，不同的是此反應(yīng)用一價(jià)銅作為催化劑，通過(guò)反應(yīng)中加入氧氣重新氧化完成催化循環(huán)。
與之類似的Hay偶聯(lián)相比Glaser偶聯(lián)有很多優(yōu)點(diǎn)，此反應(yīng)中用到的Cu-TMEDA絡(luò)合物催化劑可以溶于很多溶劑，所以反應(yīng)應(yīng)用性更廣。
Cadiot-Chodkiewicz 偶聯(lián)可以合成非對(duì)稱的二炔可以作為此反應(yīng)的互補(bǔ)反應(yīng)，很有價(jià)值。
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