經過三十多年的發展，Heck 反應的應用也越來越廣泛。每一類反應根據其特點的不同由可以分成幾類。
（一）分子內的 Heck 反應
生成烯基取代的反應
該類反應主要用于生成環外雙鍵。環外雙鍵是合成上一大難題，該反應成功的應用具有重大意義。目前已有合成的報道。
該反應還被 Danishefsky 應用到全合成 Taxol 上
示例：
分子內 Heck 反應化生成環外雙鍵示例分子內 Heck 反應化生成環外雙鍵示例
A stirred solution of 1 (98 mg, 0.19 mmol), triethylmine (0.32 mL, 2.3 mmol) and catalytic tetrakis(triphenylphosphine)palladium(0) (ca. 5 mg, 4 μmol) in 2.4 mL of acetonitrile was heated at 80 ℃ in a sealed tube under an argon atmosphere for 10 h. The reaction mixture turned dark orange after ca. 10 min, and the catalyst plated out on the walls of the tube as a shiny layer of palladium metal upon completion of the reaction. The reaction mixture was cooled to room temperature; the reaction was quenched with aqueous NaHCO 3 (15 mL), and the mixture was extracted with EtOAc (4×10 mL). The organic extracts were washed with aqueous NaHSO 3 (1×15 mL), water (1×15 mL), and brine (1× 15 mL) and dried over MgSO 4 . Filtration, concentration, and purification of the orange residue by flash column chromatography (45:55 Et 2 O/hexanes) gave 66 mg (90%) of 19 as a colorless solid: mp 193-194 ℃; Rf = 0.29 (8:2 Et 2 O/hexanes).
2.形成季碳中心的反應
從 20 世紀 80 年代早期研究以來得到了廣泛的應用。1989 年，Shibasaki 和 Overman首先報道不對稱 Heck 反應.
實例
A mixture of Pd 2 (dba) 3 ·CHCl 3 (360 mg, 0.347 mol), (s)-BINAP (504 mg, 0.809 mol),and N,N-dimethylacetamide (DMA, 21 mL) was stirred at room temperature for 65 min. To the resulting orange solution was added a solution of compound 1 (1.82 g, 3.51 mol),1,2,2,6,6-pentamethylpiperidine (3.2 mL, 18 mmol), and DMA (18 mL), and the reaction was heated at 100 ℃ for 90 min. The result dark solution was poured into half-saturated aqueous NaHCO 3 (100 mL) and extracted with ether (3 × 150 mL). The combined organic extracts were washed with brine (100 mL), dried (MgSO 4 ), and concentrated, and the residue was purified by sgc (9:1 → 1:1 hexane-EtOAc) to give oxindole enoxysilane compound 2 (1.29 g,94%) as a 98:2 mixture of geometric isomers: [α] 25 D –81 o (c 0.61 C 6 H 6 ).
