芳香族直接氟化法一般采用F2-N2體系，對反應容器及反應條件控制的要求較高，而且用該方法時易產生芳環上二取代或多取代副產物，如要得到一取代為主產物，一般要在芳環上有一個強拉電子的定位基團（硝基、羰基等）例如：
近年來，隨著氟化學研究的發展，出現了一些溫和的氟代試劑（F-TEDA-BF3 SelectfluorTM等），使得芳環上直接氟代制備芳香單氟代物更簡單易行，如：
實例：
Procedure：A solution of the pyrrole compound 1 (0.33 g,2.00 mmol, 1.0 equiv) and Selectfluor? (0.71 g, 2.00 mmol, 1.0 equiv) in MeCN (20 mL) was refluxed in a MLSSTART 1500 microwave synthesizer at 70 to 72 °C for 5 min. The reaction was quenched by addition of 50 mL H2O to the cooled solution followed by the addition of 50 mL CHCl3. The layers were separated and the aqueous phase was extracted with CHCl3 (3 x50 mL). The combined organic phases were dried with MgSO4 and the solvent was removed under reduced pressure, followed by flash column chromatography PE/TBME (15:1) to afforded 2 (0.15 g, 40%) as light yellow oil.
芳環碳氫鍵氟化方法匯總
除了上述方法外，本文我們整理了部分芳環的其他直接氟化方法，分享給大家，如果有沒有涉及到的實用方法，小伙伴們也可以推薦給我們。
來源：覽博網
