此反應(yīng)是Hunsdiecker反應(yīng)反應(yīng)的改進(jìn)法。羧酸在四乙酸鉛和氯化鋰作用下加熱脫羧氯代得到氯化烷烴的反應(yīng)。反應(yīng)中四乙酸鉛和氯化鋰反應(yīng)生成氯氣，直接進(jìn)行反應(yīng)。
反應(yīng)機(jī)理
和Hunsdiecker反應(yīng)反應(yīng)類似，也是自由基機(jī)理。
反應(yīng)操作
Cyclobutyl chloride (2). To a solution of cyclobutanecarboxylic acid 1 (100 mg, 10 mmol) in PhH (10 mL) was added Pb(OAc)4 (2 g, 4.5 equiv) and the mixture was stirred at 20 ℃ until it became homogeneous. Anh LiCl (240.4 mg, 6.2 mmol) was added under N2 and the mixture was heated at 81 ℃. Workup afforded 90.5 mg of 2 (100%).
【Kochi JK, J Org Chem., 1965, 30, 3265】
相關(guān)文獻(xiàn)
1 Kochi JK J Org Chem 1965 30 3265
2R Kochi JK Org React 1972 19 326
3 Grob CA Synthesis 1973 493
4 Roy S Steroids 1982 39 537
5 Kapustina NI Russ Chem Bull Int 2004 53 2200
編譯自：Organic Syntheses Based On Name Reactions, 3RdEd, A. Hassner, Page 263-264.
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Cristol-Firth脫羰鹵代反應(yīng)
Hunsdiecker反應(yīng)
